Research progress on the pharmacological activity, biosynthetic pathways, and biosynthesis of crocins

• Zhongwei Hua,
• Nan Liu and
• Xiaohui Yan

Beilstein J. Org. Chem. 2024, 20, 741–752, doi:10.3762/bjoc.20.68

• isolated from the fruit of Gardenia jasminoides Ellis and the stigma tissue of Crocus sativus L. Crocins are the main active ingredients of C. sativus, a precious medicinal plant known as the "gold of spices". They are also responsible for the characteristic red color of saffron. Compounds of the crocin

New variochelins from soil-isolated Variovorax sp. H002

• Jabal Rahmat Haedar,
• Aya Yoshimura and
• Toshiyuki Wakimoto

Beilstein J. Org. Chem. 2024, 20, 692–700, doi:10.3762/bjoc.20.63

• , including soil-isolated plant pathogens. Results and Discussion Isolation and structure elucidation In this study, we explored the secondary metabolite potential of the soil-isolated Variovorax sp. H002, domesticated from the Medicinal Plant Garden of the Faculty of Pharmaceutical Sciences, Hokkaido

Sulfur-containing spiroketals from Breynia disticha and evaluations of their anti-inflammatory effect

• Ken-ichi Nakashima,
• Naohito Abe,
• Masayoshi Oyama,
• Hiroko Murata and
• Makoto Inoue

Beilstein J. Org. Chem. 2023, 19, 1604–1614, doi:10.3762/bjoc.19.117

• Tesque) were used for column chromatography (CC). Silica gel 60 F254 and RP-18 F254S (Merck) were used for TLC analysis. Plant material B. disticha was cultivated in the greenhouse of Setsunan University medicinal plant garden (Osaka, Japan) in September 2014. Taxonomic identification was performed by an

Secondary metabolites of Diaporthe cameroonensis, isolated from the Cameroonian medicinal plant Trema guineensis

• Bel Youssouf G. Mountessou,
• Élodie Gisèle M. Anoumedem,
• Blondelle M. Kemkuignou,
• Yasmina Marin-Felix,
• Frank Surup,
• Marc Stadler and
• Simeon F. Kouam

Beilstein J. Org. Chem. 2023, 19, 1555–1561, doi:10.3762/bjoc.19.112

• cameroonensis, isolated from the root of Trema guineensis, a Cameroonian medicinal plant from the family Ulmaceae [11]. Results Structural elucidation Diaporthe cameroonensis, which showed an interesting high-performance liquid chromatography–diode array detector–high-resolution mass spectrometry (HPLC–DAD–HRMS

• medicinal plant, Trema guineensis led to the isolation of seventeen secondary metabolites, including two previously undescribed polyketides, namely 5,7-dimethylpseudopithonone (1) and 3,9-diacetylalternariol (2). This study has contributed further to our knowledge of the metabolic diversity within Diaporthe

Cassane diterpenoids with α-glucosidase inhibitory activity from the fruits of Pterolobium macropterum

• Sarot Cheenpracha,
• Ratchanaporn Chokchaisiri,
• Lucksagoon Ganranoo,
• Sareeya Bureekaew,
• Thunwadee Limtharakul and
• Surat Laphookhieo

Beilstein J. Org. Chem. 2023, 19, 658–665, doi:10.3762/bjoc.19.47

• of isolated compounds was evaluated, and compounds 1 and 3 showed significant α-glucosidase inhibitory activity with IC50 values of 66 and 44 μM. Keywords: α-glucosidase inhibitory activity; cassane diterpenoid; Fabaceae; medicinal plant; Pterolobium macropterum; Introduction Diabetes mellitus is a

• ]. Pterolobium macropterum Kurz is a woody climbing shrub that is mainly distributed in the northern Thailand. Its roots are used in the medicinal plant therapy to treat toothache, fever, and to promote wound healing [11]. Previous phytochemical investigations of P. macropterum have revealed that this plant is a

Glycosylated coumarins, flavonoids, lignans and phenylpropanoids from Wikstroemia nutans and their biological activities

• Meifang Wu,
• Xiangdong Su,
• Yichuang Wu,
• Yuanjing Luo,
• Ying Guo and
• Yongbo Xue

Beilstein J. Org. Chem. 2022, 18, 200–207, doi:10.3762/bjoc.18.23

• plants of this species are used as a folk medicine for the treatment of arthritis, mastitis, and pain relief [2]. Interestingly, the traditional medical usages are highly consistent with the phytologically related medicinal plant species W. indica that has already been approved to use as a prescription

• μg/mL). Conclusion In this paper, the new bis-coumarin glucoside wikstronutin (1) was isolated from the stems and roots of the medicinal plant species W. nutans, together with three known bis- and tricoumarin glucosides 2–4, two flavonoid glycosides 5 and 6, and eleven lignan glucosides 7–17. Their

A novel methodology for the efficient synthesis of 3-monohalooxindoles by acidolysis of 3-phosphate-substituted oxindoles with haloid acids

• Li Liu,
• Yue Li,
• Tiao Huang,
• Dulin Kong and
• Mingshu Wu

Beilstein J. Org. Chem. 2021, 17, 2321–2328, doi:10.3762/bjoc.17.150

• Li Liu Yue Li Tiao Huang Dulin Kong Mingshu Wu Key Laboratory of Tropical Medicinal Plant Chemistry of the Ministry of Education, College of Chemistry & Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan Province, P. R. China School of Pharmaceutical Sciences, Hainan Medical

Chemical constituents of Chaenomeles sinensis twigs and their biological activity

• Joon Min Cha,
• Dong Hyun Kim,
• Lalita Subedi,
• Zahra Khan,
• Sang Un Choi,
• Sun Yeou Kim and
• Chung Sub Kim

Beilstein J. Org. Chem. 2020, 16, 3078–3085, doi:10.3762/bjoc.16.257

• ) is a deciduous or semi-evergreen tree widely distributed in East Asia including Korea, Japan, and mainland China. The fruits of this medicinal plant have been used on its own or in combination with other medicinal herbs to treat diarrhea, vomiting, myalgia, and common cold [1]. Previous phytochemical

Synthesis of the aglycon of scorzodihydrostilbenes B and D

• Katja Weimann and
• Manfred Braun

Beilstein J. Org. Chem. 2019, 15, 610–616, doi:10.3762/bjoc.15.56

• multiple phenolic functionality. These natural products that form as secondary metabolites on a branch of flavonoid biosynthesis found wide interest for their various biological effects like anti-oxidative and biofouling-preventing activity [1]. From crude extracts of the Mongolian medicinal plant

A concise enantioselective synthesis of the guaiane sesquiterpene (−)-oxyphyllol

• Martin Zahel and
• Peter Metz

Beilstein J. Org. Chem. 2013, 9, 2028–2032, doi:10.3762/bjoc.9.239

• ; Introduction The hydroazulene framework is present in many natural products that are often associated with interesting biological properties [1][2]. The guaiane sesquiterpene (−)-oxyphyllol (1) has been isolated from the roots of the Thai medicinal plant Phyllanthus oxyphyllus [3]. A recent enantioselective